鍗楁搗鎵�鏋勫緩瀹屾垚榛勯硩媯橀卜鏌撹壊浣撴按騫沖熀鍥犵粍鍥捐氨
榪戞棩錛屼腑鍥芥按浜х瀛︾爺絀墮櫌鍗楁搗姘翠駭鐮旂┒鎵�閬椾紶鑲茬鍒涙柊鍥㈤槦瀵歸粍槌嶆椴峰熀鍥犵粍瑙ｆ瀽鐨勭爺絀跺彇寰楅噸瑕佽繘灞曪紝鐩稿叧鐮旂┒鎴愭灉鍦ㄥ浗闄呯煡鍚嶆湡鍒奊enomics涓婂湪綰垮彂琛紝鏈卞厠璇氬壇鐮旂┒鍛樹負璁烘枃絎竴浣滆�咃紝寮犳鏄岀爺絀跺憳涓洪�氳浣滆�呫�傝鐮旂┒寰楀埌鍐滀笟鍐滄潙閮ㄨ儲鏀夸笓欏廣�佸箍涓滅渷瀹為獙瀹ら」鐩�佷腑鍥?涓滅洘嫻蜂笂鍚堜綔鍩洪噾絳夊叡鍚岃祫鍔┿�?/p>
榛勯硩媯橀卜鏄崕鍗楀捀娣℃按鍖哄煙涓昏鍏繪畺鐨勯奔綾諱箣涓�錛屽吀鍨嬫渤鍙ｉ奔綾伙紝鑲夎川緇嗗錛屽懗閬撻矞緹庯紝娣卞彈娑堣垂鑰呮榪庛�備絾鏄紝闀挎湡浠ユ潵錛岄粍槌嶆椴烽噹鐢熻嫍縐嶇敓闀跨浉瀵圭紦鎱紝浜熷緟寮�灞曢粍槌嶆椴風敓闀垮揩銆佹姉鐥呰兘鍔涘己鐨勬柊鍝佺閫夎偛錛涚粯鍒墮粍槌嶆椴峰熀鍥犵粍綺劇粏鍥捐氨錛屽彲涓哄叾閲嶈緇忔祹鎬х姸鐨勯仐浼犺В鏋愬拰鍏ㄥ熀鍥犵粍閫夋嫨鑲茬鎻愪緵鍩虹鏁版嵁銆?/p>
寮犳鏄岀爺絀跺憳鍥㈤槦鍒╃敤絎簩銆佷笁浠ｆ祴搴忓拰Hi-C鏌撹壊浣撴瀯璞℃崟鑾鋒妧鏈紝鏋勫緩浜嗛粍槌嶆椴鋒煋鑹蹭綋姘村鉤鐨勫熀鍥犵粍鍥捐氨錛屽叾鍩哄洜緇勫ぇ灝忎負806Mb錛宑ontig N50鍜宻caffold N50鍒嗗埆杈懼埌2.60 Mb鍜?0.2 Mb錛屽埄鐢℉i-C鎶�鏈垚鍔熷皢90.8%鐨勭粍瑁呭簭鍒楁寕杞藉埌24鏉℃煋鑹蹭綋涓婏紝閴村畾鍑?9,631铔嬬櫧緙栫爜鍩哄洜錛屽熀鍥犲鏃忓垎鏋愭樉紺篈RRDC3 鍜?GSTA鍩哄洜瀹舵棌鍦ㄥ箍鐩愭�х殑椴風楸肩被涓嚭鐜頒簡澶ч噺鎵╁紶錛屼負鍚庣畫鐮旂┒椴風楸肩被娓楅�忓帇璋冭妭鏈哄埗鎻愪緵浜嗛噸瑕佸弬鑰冦�?/p>
璁烘枃閾炬帴錛?a >https://doi.org/10.1016/j.ygeno.2021.04.017銆?/p>
榛勯硩媯橀卜鍩哄洜緇勫簭鍒楀浘璋?/p>
榛勯硩媯橀卜ARRDC3鍩哄洜瀹舵棌淇℃伅
綺ゅ叕緗戝畨澶?4010502001742鍙?/a>